Enzyme evolution and the temperature dependence of enzyme catalysis
نویسندگان
چکیده
منابع مشابه
Eurythermalism and the temperature dependence of enzyme activity.
The "Equilibrium Model" has provided new tools for describing and investigating enzyme thermal adaptation. It has been shown that the effect of temperature on enzyme activity is not only governed by deltaG(double dagger)(cat) and deltaG(double dagger)(inact) but also by two new intrinsic parameters, deltaH(eq) and T(eq), which describe the enthalpy and midpoint, respectively, of a reversible eq...
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15 صفحه اولEnzyme surface rigidity tunes the temperature dependence of catalytic rates.
The structural origin of enzyme adaptation to low temperature, allowing efficient catalysis of chemical reactions even near the freezing point of water, remains a fundamental puzzle in biocatalysis. A remarkable universal fingerprint shared by all cold-active enzymes is a reduction of the activation enthalpy accompanied by a more negative entropy, which alleviates the exponential decrease in ch...
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We determined the crystal structure of the liganded form of alpha-aminotransferase from a hyperthermophile, Pyrococcus horikoshii. This hyperthermophilic enzyme did not show domain movement upon binding of an acidic substrate, glutamate, except for a small movement of the alpha-helix from Glu16 to Ala25. The omega-carboxyl group of the acidic substrate was recognized by Tyr70* without its side-...
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ژورنال
عنوان ژورنال: Current Opinion in Structural Biology
سال: 2020
ISSN: 0959-440X
DOI: 10.1016/j.sbi.2020.06.001